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Abstract #1797

Correlation Between Plaque Counts and Metabolite Concentrations in Transgenic Mouse Model of Alzheimers Disease

Malgorzata Marjanska1, Stephen D. Weigand2, Geoffry L. Curran2, Thomas M. Wengenack2, Joseph F. Poduslo2, Michael Garwood1, Clifford R. Jack, Jr. 2

1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; 2Mayo Clinic College of Medicine, Rochester, MN, United States

Previously, reduced levels of N-acetylaspartate (NAA) and glutamate (Glu) were observed in various mouse models of Alzheimers disease (AD). Dramatic increase in the concentration of myo-inositol (mIns) with age was observed for APP-PS1 mouse model of AD. Additionally, the treatment of transgenic AD mice with anti-Aβ antibody regimes appeared to slow the rate at which mIns normally increases in AD mice. In this project, we looked at the correlation between concentrations of metabolites obtained in vivo using 1H MRS just prior to sacrifice and the plaque counts obtained from histological Thio-S stained brain sections. Higher plaque counts were associated with lower NAA values and higher mIns values.