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Abstract #1800

In Vivo 1H-MRS Reveals Neurometabolic Effects of a High Fat Diet

Janna L. Harris1, William M. Brooks1, In-Young Choi1, 2, Hung-Wen Yeh3, John A. Stanford4

1Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States; 2Department of Neurology, University of Kansas Medical Center; 3Department of Biostatistics, University of Kansas Medical Center; 4Department of Molecular and Integrative Physiology, University of Kansas Medical Center

Recent evidence suggests a link between consumption of a high fat (HF) diet and cognitive decline. In order to better understand the effects of excess fat consumption on brain function, we maintained rats on a HF diet or standard low fat chow for 16 weeks before acquiring 1H-MRS in the hippocampus and striatum at 9.4T. In animals on the HF diet we observed changes in several metabolites including total creatine, total choline, glutamine, inositol, and glutathione. Collectively these data suggest that a HF diet produces disturbances in brain energy metabolism, cell membrane biodynamics, astroglial populations, and oxidative stress