Ravi Prakash Reddy Nanga1, David R. Roalf2, Kejia Cai1, Mark Elliott1, Hari Hariharan1, James Loughead2, Harish Poptani1, Ravinder Reddy1, Ruben C. Gur2
1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Psychiatry, University of Pennsylvania, Philadelphia, PA, United States
Ultra-high field neuroimaging provides enhanced sensitivity and spectroscopic resolution. However, the increased field strength has several limitations, especially in deep brain regions which are prone to severe field inhomogeneities. Here, we show accurate and reliable quantification of glutamate/glutamine in deep brain structures (amygdala and hippocampus) at 7.0T. Given the importance of these deep brain structures in memory, emotion and other cognitive processes, accurate quantification could provide insight into the well-documented volumetric and functional differences in a variety of neuropsychological disorders.