Manoj K. Sammi1, Yosef A. Berlow1, 2, Thomas M. Barbara1, Audrey H. Selzer1, John W. Grinstead3, Edward Kim4, Dennis Bourdette4, William D. Rooney1, 2
1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States; 2Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States; 3Siemens Medical Solutions, Portland, OR, United States; 4Department of Neurology, Oregon Health & Science University, Portland, OR, United States
Mitochondrial dysfunction has been hypothesized to be a risk factor for neurodegeneration that leads to Multiple Sclerosis symptoms. Current work investigates and compares the normalized phosphorus metabolite signals in the brain over the same volume of interest in MS and healthy control subjects using phosphorus spectroscopic imaging at 7T while correcting for the signal contributions of gray matter, white matter, cerebrospinal and skeletal muscle tissue.