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Abstract #1820

Metabolite 1H Transverse Relaxation Rates Measured in the Healthy Young Versus Elderly Human Brain at 4 T

Uzay E. Emir1, Malgorzata Marjanska1, Dinesh Deelchand1, Melissa Terpstra1

1University of Minnesota, Minneapolis, MN, United States

Differences in T2 among experimental groups can confound quantification of metabolite concentrations. Existence of such differences in young versus elderly human subjects is controversial. This study used STEAM spectroscopy at several echo times to measure T2 at ultra high magnetic field (4 T) in 29 young (age 18-22) and 32 elderly (age 70+) subjects. Artifact free spectra allowed for reliable determination of signal strengths via LCModel, which led to good fitting of the data to the T2 relaxation curve for each metabolite. The T2's were faster in the elder than in the young subjects (p<0.01) for all metabolites.