Incorporating DTI-Derived Orientation Information Into a Double-PFG Framework

Evren Ozarslan¹, ², Michal E. Komlosh¹, ², Peter J. Basser¹

Double pulsed field gradient (double-PFG) MR technique could be an important tool that provides microstructural information from tissue. In this study, orientation information obtained from an independent DTI acquisition was incorporated into a theoretical double-PFG framework enabling accurate measurements of cell size. DTI data, acquired in tandem, may reduce the sampling burden of double-PFG acquisitions when the underlying fiber orientation is known approximately, as is the case in spinal cord. The method is used on a celery data set to estimate the cell size in the vascular bundles of the celery stalk.