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Abstract #1835

Incorporating DTI-Derived Orientation Information Into a Double-PFG Framework

Evren Ozarslan1, 2, Michal E. Komlosh1, 2, Peter J. Basser1

1STBB / PPITS / NICHD, National Institutes of Health, Bethesda, MD, United States; 2Center for Neuroscience and Regenerative Medicine, USUHS, Bethesda, MD, United States

Double pulsed field gradient (double-PFG) MR technique could be an important tool that provides microstructural information from tissue. In this study, orientation information obtained from an independent DTI acquisition was incorporated into a theoretical double-PFG framework enabling accurate measurements of cell size. DTI data, acquired in tandem, may reduce the sampling burden of double-PFG acquisitions when the underlying fiber orientation is known approximately, as is the case in spinal cord. The method is used on a celery data set to estimate the cell size in the vascular bundles of the celery stalk.