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Abstract #1850

Comparison of Different Models for Analysis of Renal Diffusion Imaging

Jinxia Zhu1, Claudia Lenz1, Markus Klarhfer1, Oliver Bieri1, Klaus Scheffler2, 3, Gregor Sommer4

1Radiological Physics, University of Basel Hospital, Basel, Switzerland; 2MRC Department, MPI for Biological Cybernetics, Tbingen, Germany; 3Department of Neuroimaging and MR-Physics, University of Tbingen, Tbingen, Germany; 4Department of Radiology, University of Basel Hospital, Basel, Switzerland

Compared to the traditional mono-exponential model, the application of more complex models (stretched exponential model, diffusional kurtosis model, and bi-exponential model) to analyze the renal diffusion weighted MRI data can result in valuable additional insight into pathological processes, for example, benign cysts and renal cell carcinoma. In this research, we compared these four different models to demonstrate that renal pathologies can be differentiated from healthy tissue by applying higher order diffusion models to DWI data consisting of multiple diffusion weightings.