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Abstract #1862

Relationship Among Markers of Cerebral Integrity with Aging

S. Andrea Wijtenburg1, Stephen McGuire2, David Sherman3, Laura M. Rowland1, Peter Kochunov1

1Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United States; 2Aerospace Medicine Consultation Division, Dayton, OH, United States; 3Neuroradiology, 59th Medical Wing, Lackland AFB, TX, United States

We used a multimodal MR protocol, which combined DTI with 1H MRS and 3D white matter lesion mapping to ascertain changes in biologically important spectroscopy markers and white matter lesion burden associated with changes in FA values. The data were collected in two samples: middle-aged and elderly healthy adults. Our findings demonstrate that age-related decline in FA values is associated with a decline in NAA concentrations in both middle-aged and elderly individuals.