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Abstract #1870

New Non-Linear Color Look-Up Table for Fractional Anisotropy Demonstrated on Multiple System Atrophy

Jiri Keller1, 2, Aaron Michael Rulseh1, Arnost Komrek3, Iva Latnerov1, Robert Rusina4, Jiri Klempr5, Katerina Zrubov6, Josef Vymazal1

1RDG, Na Homolce Hospital, Prague 5, Prague, Czech Republic; 2Neurology, 3rd Medical Faculty, Charles University, Prague, Prague 10, Czech Republic; 3Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic; 4Department of Neurology, Faculty Thomayer Hospital, Czech Republic; 5Department of Neurology and Center of Clinical Neuroscience, 1st Faculty of Medicine, Charles University; 6Department of Neurology, 2nd Faculty of Medicine, Charles University, Czech Republic

To facilitate the assessment of fractional anisotropy (FA) in daily clinical practice, we propose a new non-linear colour look-up table (LUT) based on healthy subject data (in the present study 76 volunteers). Our approach can be used to build a site-specific LUT, especially relevant considering the variability of signal-to-noise ratio. The LUT has been tested on a cohort 17 multiple system atrophy (MSA) subjects, 13 Parkinson disease subjects and 17 healthy volunteers. Three blinded radiologists achieved an average sensitivity of 88% (65-100%) and specificity of 93% (80-100%) in differentiating MSA from other groups solely using this method.