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Abstract #1872

Evaluation of Pre-Defined Atlas Based ROIs for the Analysis of DTI Data in Normal Brain Development.

Amritha Nayak1, 2, Lindsay Walker1, 2, Carlo Pierpaoli, The Brain Development Cooperative Group3

1STBB-PPITS, National Instritutes of Health, NICHD, Bethesda, MD, United States; 2Center for Neuroscience and Regenerative Medicine (CNRM), Bethesda, MD, United States;

We have evaluated the Atlas based image analysis using Large Deformation Diffeomorphic Metric Mapping (LDDMM) on DTI age specific group average brains that have been created from a large cohort (0-22 yrs) of subjects that were recruited as part of the NIH MRI Study of Normal Brain Development project. Our goal has been to understand the utility of the atlas based method in accurately handling and extracting diffusion values that are representative both of the underlying structure and normal development.