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Abstract #1894

An SSFP-Based Pulse Sequence for Measuring Hyperpolarized Gas Diffusion

Karen Mooney1, John P. Mugler III2, Gordon D. Cates Jr. 1, 2, W. A. Tobias1, G. Wilson Miller2

1Physics, University of Virginia, Charlottesville, VA, United States; 2Radiology, University of Virginia, Charlottesville, VA

The sensitivity of hyperpolarized helium to diffusion provides an opportunity to generate diffusion weighting based on asymmetric signal attenuation in a balanced SSFP sequence, by placing diffusion-sensitizing gradients in selected TR windows. We present a pulse sequence designed to take advantage of this effect, and use it make accurate measurements of the helium diffusion coefficient at very short timescales.