Maximal Entropy Tractography

Lawrence R. Frank¹, David Meyer²

We have developed a fiber tractography method that computes the maximum entropy trajectories between locations and depends upon the global structure of the diffusion tensor field. Computation of the pathways requires only solving a simple eigenvector problem for which efficient numerical routines exist, and a simple iterative computation. This method has potential significance for a wide range of applications, including studies of brain connectivity.