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Abstract #1918

Within Subject Reproducibility and Between Subject Variability of Super-Resolution Track-Weighted Imaging

Lisa Willats1, David Raffelt1, Robert Elton Smith1, 2, Jacques-Donald Tournier1, 2, Alan Connelly1, 2, Fernando Calamante1, 2

1Brain Research Institute, Florey Neuroscience Institutes, Melbourne, Victoria, Australia; 2Department of Medicine, University of Melbourne, Victoria, Australia

Recently several novel image contrasts derived from whole-brain fibre tracking-data (tractograms) have been introduced. The novel contrasts of these track-weighted imaging (TWI) methods may provide important information for clinical studies. However, before they can be used reliably to generate quantitative measures, it is important to characterise the within-subject intra-session and inter-session reproducibility, and between-subject variability. In this work we investigate the within-subject reproducibility (both intra-session and inter-session), and between-subject variability of TWI for a number of different contrasts across multiple subjects.