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Abstract #1928

Structural Connectivity of the Left Anterior Temporal Lobe: A Diffusion Tensor Imaging Study

Nico D. Papinutto1, 2, Sebastiano Galantucci, 23, Roland G. Henry2, Jorge Jovicich4, Maria Luisa Gorno-Tempini2

1CIMeC, University of Trento, Mattarello , TN, Italy; 2University of California San Francisco, San Francisco, CA, United States; 3Scientific Institute and University Hospital San Raffaele, Milano, MI, Italy; 4CIMeC, University of Trento, Mattarello, TN, Italy

The anterior temporal lobe (ATL) is crucial for higher order language functions, such as semantic memory, and it is involved in behavioral regulation. Evidences of ATL damage are found in many neurological diseases, but little is known about the structural connections of this area with the rest of the brain. In this study, by using DTI on 21 healthy subjects, we explore the architecture of the left ATL connectivity with many ipsilateral regions of the brain (in particular the areas known to have a key role in language) and we segment the ATL based on these connectivity patterns.