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Abstract #1948

Improved Vascular Model -Based Analysis for DSC-MRI Perfusion Quantification

Amit Mehndiratta1, Bradley J. MacIntosh2, David E. Crane2, Stephen J. Payne3, Michael A. Chappell3

1Institute of Biomedical Engineering , University of Oxford, Oxford, Oxfordshire, United Kingdom; 2Medical Biophysics, University of Toronto, Toronto, ON, Canada; 3Institute of Biomedical Engineering, University of Oxford, Oxford, Oxfordshire, United Kingdom

A vascular model-based Bayesian solution for perfusion quantification of DSC-MRI has previously been proposed. However, estimates from the method are potentially biased due to the use of priors estimated from the data within the analysis. Here a modification is proposed that introduces a further parameter into the model resulting in higher accuracy and providing an independent estimate of MTT.