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Abstract #1963

DCE-PWI: 3D T1-Measurement as Function of Time or Flip Angle?

Irene Klrke Mikkelsen1, David Alberg Peters2, Anna Tietze, 13

1Centre for Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark; 2Dept. of Clinical Engineering, Central Denmark Region; 3Dept. of Neuroradiology, Aarhus University Hospital

Dynamic Contrast Enhanced Perfusion Weighted Imaging (DCE-PWI) is usually measured with a 3D FLASH sequence. The required baseline T1 measurement is also measured with the 3D sequence, and for the sake of speed, the measurement is often performed by measuring the signal for a range of flip angles instead of as a function the inversion (or saturation) time. This work investigates how off-set in flip angles in the presence of B1 inhomogeneities propagates into large errors in the T1 estimates. The errors are markedly reduced when the measurement is performed as a function of time, even though a preparation pulse is then needed.