Ping Wang1, Jiangsheng Yu1, Yiqun Xue1, Xia Zhao1, Mark Rosen1, Hee Kwon Song1
1Radiology, University of Pennsylvania, Philadelphia, PA, United States
In conventional DCE-MRI, flip angle accuracy is important in accurately determining perfusion parameters. It has been shown previously that large flip angle deviations can occur throughout the body, resulting in erroneous perfusion measures. Recently, a simpler method for computing perfusion was proposed, in which the absolute signal difference is used without the need for baseline T1, contrast agent concentration measurements, or flip angle assumptions. In this study numerical simulations were used to systematically compare the performance of the signal difference methodology with the conventional technique in the presence of flip angle deviations.