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Abstract #1973

A Four Site Linear Exchange Model for DCE-MRI

Matthias Christian Schabel1, 2

1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States; 2Radiology, Utah Center for Advanced Imaging Research, Salt Lake City, UT, United States

We have developed a four site linear exchange model (4SLX) for pharmacokinetic analysis of DCE-MRI data. This model incorporates separate compartments for intracellular, extracellular extravascular, blood plasma, and erythrocyte water. Comparison of parameter estimates obtained using a simpler two-compartment exchange (2CX) model that assumes the fast water exchange limit with those obtained from the 4SLX in a human glioma show modest but statistically significant changes in parameter estimates.