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Abstract #1983

Novel Pharmacokinetic Model for Fractional Blood Volume Quantification with the Rapid Steady State T1 MRI Technique in Tumors with Gd-DOTA Permeable Vasculature

Teodora-Adriana Perles-Barbacaru1, Michel Sarraf1, Regine Farion1, Marie France Nissou1, Boudewijn van der Sanden1, Francois Berger1, Hana Lahrech1

1Grenoble Institute of Neurosciences, INSERM U836, Grenoble, France

A blood volume fraction (BVf) in a C6 rat brain tumor model is quantified with the Rapid Steady State T1 (RSST1) technique and Gd-DOTA using a novel pharmacokinetic model to account for transendothelial contrast agent leakage. The BVf is validated with a ΔR2* steady state technique employing a blood pool contrast agent and histologically. The advantage of the RSST1 technique over conventional dynamic contrast enhanced techniques is that it does not require measurement of the arterial input function, making BVf quantification straightforward and easy to apply in the clinical routine.