Abstract #1991

Age-Related Changes of Prostatic Tissues in Healthy Adults Measured by Kinetic Parameters from DCE MRI

Wenchao Cai¹, Feiyu Li¹, Yi Dang², Jue Zhang²,³, Xiaoying Wang¹,², Xuexiang Jiang¹

¹Radiology, Peking University First Hospital, Beijing, China; ²Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China; ³College of Engineering, Peking University, Beijing, China

Purpose:To identify age-related changes and differences in the kinetic parameters obtained from DCE-MRI within the prostate gland in heathy adult men. Methods:A total of 68 heathy male volunteers were recruited into the study. The patients were divided into three age groups(10~30years,31~50years and >50years). The DCE-MRI examinations were performed on a clinical 3.0 T MR scanner. Post-procession of DCE-MRI data was conducted in the Matlab to obtain the Ktrans,Vep and Ve values. Results:The Variance(ANOVA) analysis identified significant differences of Ktrans , Kep among the three age groups within the PZ (all P<0.05),While Ve showed no statistically significant difference. Conclusion:Our results shows that there is a decrease trend of Ktrans and Kep along with age increase within the prostate PZ of healthy adults.