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Abstract #2020

The Effect of Caffeine on Cerebral Blood Flow in a Test-Retest Study Using Pseudo-Continuous ASL

Joost PA Kuijer1, Petra JW Pouwels1, Ajit Shankaranarayanan2, David Alsop3, Frederik Barkhof4, Rudolf Verdaasdonk1

1Physics and Medical Technology, VU University Medical Center, Amsterdam, Netherlands; 2Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States; 3Radiology, Beth Harvard Medical School, Israel Deaconess Medical Center, Boston, MA, United States; 4Radiology, VU University Medical Center, Amsterdam, Netherlands

Caffeine intake is a known confounder in ASL studies. A test-retest study is presented with intervention using a single serving of coffee and a control group, after a 4-hour abstinence. Ten minutes after coffee intake a significant effect of caffeine on CBF was found. No significant change in CBF was found for the control group. Additionally, a lower group variance was found during retest, suggesting a scanner habituation time may lower group variance.