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Abstract #2028

IVIM and DSC Metrics Are Heightened in Rat C6 Brain Tumors.

Alexander David Cohen1, Peter S. LaViolette2, Kimberly Pechman1, Kathleen M. Schmainda, 12

1Biophysics, Medical College of Wisconsin, Wauwatosa, WI, United States; 2Radiology, Medical College of Wisconsin, Wauwatosa, WI, United States

The Intravoxel Incoherent Motion (IVIM) theory assumes diffusion within live tissue is more complex than simple random Brownian motion. The theory includes a faster water diffusion component representing the microcirculation of blood through capillaries, and there remains some debate as to what this perfusion fraction actually represents. Rats injected with a C6 glioma were imaged with multiple-bvalue DWI and DSC. IVIM and rCBV were compared in tumor versus normal brain. rCBV and IVIM metrics were found to be heightened in tumors compared to normal brain indicating IVIM may be biologically relevant in brain tumors.