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Abstract #2037

Blood Flux Imaging in Rodent Brain Using FENSI

Olivier Reynaud1, Luisa Ciobanu1

1Neurospin, CEA, Saclay, France

This study uses the FENSI technique as an alternative to ASL to characterize and quantify non-invasively tumor microvascular flux in a rat glioma model (9L). We highlight a significant increase (1248%) in tumor blood flux at early developmental stages (tumor size < 2mm). At late stages (tumor size > 3mm) we observe tumor compartmentalization with the presence of a hypovascularized core (5511L/min/cm) and a peripheral region presenting similar blood flux (8323L/min/cm) as the healthy contralateral side. The different regions found in our FENSI flux maps correlate well with histological results which reflect endothelial cell concentrations (CD31 staining).