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Abstract #2039

Cross Validation of Retinal and Choroidal Blood Flow Using Arterial Spin Labeling MRI and Fluorescent Microsphere

Yen-Yu Ian Shih1, Guang Li1, Bryan H. De La Garza1, Lin Wang2, Timothy Q. Duong1

1Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; 2Devers Eye Institute, Legacy Clinical Research and Technology Center, Portland, OR, United States

: This study reports the cross validation of retinal and choroidal blood flow in rats using microsphere and ASL MRI technique. The retinal and choroidal blood flows were 1.2 and 8.1 ml/g/min, respectively as measured by MRI and 9.1 and 73 gl/min as measured by microsphere. Taking the wet weight of the retina (5-35 mg), the retinal blood flow measured by microsphere in the present study ranged 0.23 V 1.64 ml/g/min, in reasonable agreement with the MRI results. ASL MRI can be used to longitudinally to image retinal and choroid blood flow in vivo.