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Abstract #2073

A Distributed Dipole Model for Estimating Epileptiform Magnetic Fields in Brain Tissue

Padmavathi Sundaram1, Darren Orbach1, Robert Mulkern1, Mukund Balasubramanian1, William Wells2

1Radiology, Children's Hospital Boston, Harvard Medical School, Boston, MA, United States; 2Radiology, Brigam and Women's Hospital, Harvard Medical School, Boston, MA, United States

In past work, we imaged epileptiform events using gradient-echo EPI and found fast MR phase changes that suggested 183 nT local magnetic fields inside neuronal tissue. Here we attempt to determine whether these fields are compatible with electrophysiology in epilepsy. Nature and strengths of magnetic fields inside the brain are largely unknown. All empirical measurements are done using MEG and are of magnetic fields outside the brain.