T1/T2 Ratio Maps for the Production of FcMRI Seed Region Based on Gray Matter Myeloarchitecture

Daniel L. Shefchik¹, Andrew S. Nencka¹, Andrzej Jesmanowicz¹, Edgar A. DeYoe¹, James S. Hyde¹

Preliminary data show that a T1 to T2 ratio map can be used to generate a seed region for fcMRI analysis. The acquisition of T1 and T2 maps in the same EPI space as fcMRI data allows a direct, one-to-one relationship between the ratio map and the functional data for a precise definition of the regions of interest. fcMRI analysis based upon seeds from mCytoarchitecture removes the need for functional scout scans from fcMRI studies, while avoiding potential confounds associated with template-based seed determination or independent component analysis.