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Abstract #2104

Anticorrelated Resting-State Functional Connectivity in Awake Rat Brain

Zhifeng Liang1, Jean King1, Nanyin Zhang1

1Psychiatry, University of Massachusetts Medical School, Worcester, MA, United States

Anticorrelated resting-state functional connectivity (RSFC) has yet been observed without the commonly used preprocessing step of global signal correction. In this study we reported robust anticorrelated RSFC that is independent of preprocessing procedures within a well documented frontolimbic circuit between the infralimbic cortex and amygdala. The finding of this study makes it possible to uncover the neurophysiologic basis of anticorrelated RSFC when combining with other techniques such as neuron recording.