Adam Q. Bauer1, Brian R. White1, Abraham Z. Snyder1, Bradley L. Schlaggar1, Jin-Moo Lee2, Joseph P. Culver1
1Radiology, Washington University in Saint Louis, Saint Louis, MO, United States; 2Neurology, Washington University in Saint Louis, Saint Louis, MO, United States
We combined resting-state functional connectivity mapping with optical intrinsic signal imaging (fcOIS). We demonstrate functional connectivity in mice through highly detailed fcOIS mapping of resting-state networks across most of the cerebral cortex. Synthesis of multiple network connectivity patterns through iterative parcellation and clustering provides a comprehensive map of the functional neuroarchitecture and demonstrates identification of the major functional regions of the mouse cerebral cortex.