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Abstract #2113

A Resting-State FMRI Study in Chronic Obstruction Pulmonary Disease

Ai Wern Chung1, James W. Dodd2, Rebecca A. Charlton3, Paul W. Jones2, Thomas R. Barrick1

1Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom; 2Division of Clinical Science, St George's University of London, London, United Kingdom; 3Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States

Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition increasingly recognised to be a multi-system disorder associated with a wide range of extra pulmonary comorbidities such as heart disease. Brain pathology and cognitive dysfunction is a potential systemic occurrence in COPD. Using functional MRI, we sought to identify differences in the underlying functional connectivity between stable COPD patients and controls, under the resting-state condition. We found wide-spread decrease in resting-state functional connectivity across the brain including the default mode and pre-frontal networks, suggesting global differences between patients and controls.