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Abstract #2117

Adrenergic Receptor Agonist Vs Antagonist Tuning Functional Connectivity in Resting State

Fatima Ali Nasrallah1, Amanda Simin1, Chen Kaina1, Kai-Hsiang Chuang1

1MRI Group, Singapore Bioimaging Consortium, Singapore , Singapore

Receptor targeted pharmaceuticals are applied to modulate neurotransmission to investigate the neural correlate of resting state functional connectivity. The 2 adrenergic receptor agonist, Medetomidine, and antagonist, Atipamezole, were used to understand the role of the adrenergic system in modulating functional connectivity. Activation of the 2 receptor caused a dosage dependant loss of interhemispheric connectivity compared to deactivation of the receptor by the antagonist which resulted in an increase in functional connectivity. This study provides an insight into the underlying basis of functional connectivity.