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Abstract #2124

Prior Cognitive State Can Influence Functional Connectivity Networks at the Individual and Group Level.

Chris Tailby1, 2, David F. Abbott1, 3, Graeme D. Jackson1, 3

1Brain Research Institute, Florey Neuroscience Institutes, Melbourne, Victoria, Australia; 2Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia; 3Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia

Previous work demonstrated that resting state functional connectivity (RSFC) measured in an individual can vary with prior cognitive state. The analysis of large multicentre data sets using RSFC is becoming increasingly widespread. It is therefore important to determine whether the dependence of RSFC on a given prior cognitive state is consistent across individuals, as this would have the potential to bias large multicentre RSFC analyses. By comparing, across 25 healthy participants, RSFC maps obtained following performance of two cognitive tasks we show that RSFC networks vary heterogeneously across subjects. Such effects can produce weak effects at the group level.