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Abstract #2197

The Relationship Between GABA Concentrations and Cerebral Hemodynamics Is Spatially Heterogeneous

Yi-Ching Lynn Ho1, Jakob Udby Blicher1, Christopher Bailey1, Torben Ellegaard Lund1, Jamie Near2, Kim Vang3, Arne Mller3, Leif stergaard4

1Center for Functionally Integrative Neuroscience (CFIN), Aarhus University, Aarhus , Denmark; 2FMRIB, Oxford University, Oxford, United Kingdom; 3PET Center, Aarhus University, Aarhus, Denmark; 4Center for Functionally Integrative Neuroscience (CFIN), Aarhus University, Aarhus, Denmark

The influence of baseline GABA on hemodynamics is a current topic of interest, with a few studies showing correlations of GABA with BOLD and hemodynamic metrics, e.g. baseline CBF. In our study, we found that the GABA-BOLD correlations appear to depend on the area under investigation. Furthermore, in areas showing significant correlations, parallel changes in PET-CBF do not seem to contribute to the relationship. A simple, linear, mechanistic relationship between GABA concentrations and hemodynamics may not exist.