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Abstract #2199

An Absolute Quantification Method for Pharmacological MRI

Yun-Hsuan Lin1, Kai-Ling Lu1, Chin-Tien Lu1, Yi-Jui Liu2, Fu-Nien Wang1

1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan; 2Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan

Absolute quantification of phMRI could benefit inter-subject comparison and longitudinal follow-up. In this study, we combined a modified Vascular-Space Occupancy (VASO) method and the phMRI technique to acquire high-resolution multi-slice absolute quantification of cerebral blood volume (CBV), and applied for methamphetamine (mAMPH) challenged phMRI on a rat model. We used single slice IR-RARE sequence to calculate absolute CBV by the VASO method with Gd-DTPA administration. Short TR as 1600ms was used to reduced the tissue interference. Then, multislice relative CBV maps calculated by the pre- and post-MION images were converted to absolute values according to the overlapped slice.