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Abstract #2350

Novel MR Method to Detect Non-Normoxic Tissue Based on Cluster Analysis of the Dynamic R2* and R1 Response to a Hyperoxic Respiratory Challenge

Stefanie Remmele1, Alois Martin Sprinkart2, Andreas Mller2, Frank Trber2, M von Lehe3, Jrgen Gieseke, 24, Sebastian Flacke, 25, Winfried A. Willinek2, Julien Sngas1, Jochen Keupp1, Hans H. Schild2, Petra Mrtz2

1Philips Research, Hamburg, Germany; 2Department of Radiology, University of Bonn, Bonn, Germany; 3Department of Neurosurgery, University of Bonn, Bonn, Germany; 4Philips Healthcare, Best, Netherlands; 5Department of Radiology, Tufts University Medical School, MA, United States

This work describes a novel approach of how to analyze the multi-parametric response to a respiratory challenge in order to differentiate normoxic from non-normoxic tissue. The technique is based on the simultaneous measurement of the change of two relaxation parameters (R1 and R2*) during inhalation of oxygen-enriched air. (dR2*,dR1) scatter-plots are used to identify tissue voxels with an response behavior presumably related to abnormal oxygen function or oxygenation. We present abnormal response maps that visualize these non-normoxic voxels for 4 patients with intracranial tumors.