Abstract #2350

Novel MR Method to Detect Non-Normoxic Tissue Based on Cluster Analysis of the Dynamic R2* and R1 Response to a Hyperoxic Respiratory Challenge

Stefanie Remmele¹, Alois Martin Sprinkart², Andreas Mller², Frank Trber², M von Lehe³, Jrgen Gieseke,²⁴, Sebastian Flacke,²⁵, Winfried A. Willinek², Julien Sngas¹, Jochen Keupp¹, Hans H. Schild², Petra Mrtz²

¹Philips Research, Hamburg, Germany; ²Department of Radiology, University of Bonn, Bonn, Germany; ³Department of Neurosurgery, University of Bonn, Bonn, Germany; ⁴Philips Healthcare, Best, Netherlands; ⁵Department of Radiology, Tufts University Medical School, MA, United States

This work describes a novel approach of how to analyze the multi-parametric response to a respiratory challenge in order to differentiate normoxic from non-normoxic tissue. The technique is based on the simultaneous measurement of the change of two relaxation parameters (R1 and R2*) during inhalation of oxygen-enriched air. (dR2*,dR1) scatter-plots are used to identify tissue voxels with an response behavior presumably related to abnormal oxygen function or oxygenation. We present abnormal response maps that visualize these non-normoxic voxels for 4 patients with intracranial tumors.