Abstract #2352

Translational Study of MOBILE (Mapping of Oxygen by Imaging Lipids Relaxation Enhancement) on a Clinical 3T Scanner: Initial Study in Comparison with R2* and R1 H2O in the Brain of Healthy Volunteers.

Florence Colliez¹, Julie Magat¹, Vincent Denolin², Thierry Duprez³, Bndicte F. Jordan¹, Bernard Gallez¹

¹Biomedical Magnetic Resonance Group, Universit Catholique de Louvain, Brussels, Belgium; ²Philips Health Care Benelux, Belgium; ³Institute of Clinical and Experimental Research, Universit Catholique de Louvain, Brussels, Belgium

The purpose of the current work was to translate the MOBILE technique, a method developed to map variations in oxygenation based on the changes in the relaxation properties of the tissue lipids by exploiting the higher solubility property of oxygen in lipids than in water, on a 3T clinical MR scanner. MOBILE consists in the selective measurement of the lipids relaxation rate with water suppression. In order to validate the technique, we compared the sensitivity of MOBILE in the brain of healthy volunteers (n=4) with changes in R2* and R1 of water with respect to an hyperoxic breathing challenge.