Anatomically Induced Regularization of Myelin Water Estimation by DW-MRI

Milos Ivkovic¹, Thanh Nguyen¹, Dushyant Kumar², Susan Gauthier², Ashish Raj²

We propose a spatially adaptive filter, based on the Diffusion-Weighted MRI, that regularizes T2 relaxometry signal with respect to neuronal direction -information otherwise unavailable in T2 relaxometry. Similar approaches can be used with other myelin content estimation techniques.