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Abstract #2404

Understanding Transverse Relaxation in Human Brain Through Its Field Dependence from 1.5 to 7T

Fumiyuki Mitsumori1, Hidehiro Watanabe1, Nobuhiro Takaya1, Michael Garwood2, Edward Auerbach2, Shalom Michaeli2, Silvia Mangia2

1National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan; 2University of Minnesota

We conducted measurements of apparent transverse relaxation rate at 1.5, 1.9, 3, 4.7, and 7T using a MASE sequence. The regional distribution of the relaxation rate was well described by a linear combination of the regional iron concentration [Fe], and the macromolecular mass fraction fM defined as 1 - water fraction. The B0-dependence of the [Fe] and fM terms was linear and quadratic, respectively. The linear dependence of the [Fe] term was similar to that reported for ferritin solution. The quadratic dependence of the macromolecular term was well explained with an exchange model of water protons with those in macromolecules.