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Abstract #2454

Fat Fraction Bias Correction Using T1 Estimates and Flip Angle Mapping

Issac Y. Yang1, Yifan Cui2, Curtis N. Wiens2, Trevor P. Wade1, Charles A. McKenzie1, 2

1Medical Biophysics, University of Western Ontario, London, Ontario, Canada; 2Physics and Astronomy, University of Western Ontario, London, Ontario, Canada

Fat fraction quantification with IDEAL requires the use of small flip angles to minimise T1 bias and therefore has reduced SNR. We employed rapid flip angle mapping to improve T1 bias correction for high flip angle acquisitions in the estimation of spinal bone marrow fat fraction in volunteers. We compared fat fraction estimation with 2 and 8 degree flip angles, with and without bias correction based on flip angle mapping. The results show the fat fractions corrected for high flip angle induced T1 bias have improved accuracy and precision compared to a low flip angle acquisition.