Matthias Alexander Dieringer1, 2, Michael Deimling, 13, Florian von Knobelsdorff-Brenkenhoff1, 2, Andreas Greiser3, Jeanette Schulz-Menger, 12, Thoralf Niendorf1, 2
1Berlin Ultrahigh Field Facility, Max-Delbrueck Center for Molecular Medicine, Berlin, Germany; 2Experimental and Clinical Research Center (ECRC), Charit Campus Buch, Humboldt-University, Berlin, Germany; 3Siemens Healthcare, Erlangen, Germany
DESPOT1/2 uses 3D acquisitions for T1/T2 quantification. For 2D acquisitions, however, short repetition times evoke T1 and flip angle dependent saturation phenomena that deform the slice profile and hence bear the potential to deem T1/T2 quantification inaccurate. Therefore, this study examines the impact of slice profile deformations on 2D T1/T2 quantification using variable flip angles in simulations, phantoms, and in-vivo in the brain. A correction method to facilitate accurate quantification of T1/T2 using 2D DESPOT1/2 along with a flip angle optimization algorithm are presented.
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