Abstract #2521

3D MR Elastography of In-Vivo Prostate Cancer and Correlation with Histology: Preliminary Results

Ramin Sahebjavaher¹,², Philippe Garteiser², Ralph Sinkus², Louis O. Gagnon³, Ali Baghani¹, Silvia Chang³, Simon Chatelin², Edward C. Jones⁴, Chris Nguan³, Larry Goldenberg³, Piortr Kozlowski⁵,⁶, Mehdi Moradi⁷, Septimiu Salcudean¹

¹Electrical and Computer Engineering, University of British Columbia, Vancouver, BC, Canada; ²Hpital Beaujon, Centre de Recherche Biomdicale Bichat Beaujon (CRB3), Paris, France; ³Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada; ⁴Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; ⁵Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; ⁶The Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, Canada; ⁷Department of Radiology, Harvard Medical School, Cambridge, MA, United States

We present our first in-vivo prostate cancer case using the trans-perineal MR elastography (MRE) method. An improved rapid imaging sequence is used to acquire waves in 3D in the entire prostate gland. The mechanical waves efficiently transferred to the entire prostate via the perineum at 70Hz. The results show that the tumours are clearly distinguishable in the viscoelastic maps and that they correlate closely with histopathology. To the best of our knowledge, this is the first in-vivo prostate cancer MRE study where the viscoelastic maps are compared to whole-mount histopathology. These results show the potential for MRE to improve staging of prostate cancer tumours.