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Abstract #2743

Simultaneous MR and Optical Imaging of Tumor Microenvironment

Mir Farrokh Salek1, Arthur Gmitro1

1Radiology, University of Arizona, Tucson, AZ, United States

Results obtained from MRI could be corroborated or complemented if they are accompanied by other independent measurements. In many applications, this combination of different methodologies would be optimum if they are done simultaneously on the subject. We report on an instrument that allows simultaneous MR and optical fluorescence imaging of mouse dorsal skin-fold window chamber. This instrument operates by relaying the optical image outside the magnet bore. Using this methodology we are able to measure vascular permeability of albumin dual labeled with GdDTPA and an optical fluorescent contrast agent.