Daniel Burje Chonde1, 2, Ciprian Catana1
1Martinos Center for Biomedical Imaging, Charlestown, MA, United States; 2Biophysics, Harvard University, Cambridge, MA, United States
An estimation of the radiotracer blood input function is essential for parametric estimation from dynamic PET data. Traditionally it is measured through invasive methods; however, it can be acquired through image-based methods. Using MR-based segmentation is thought to provide the most accurate arterial definition, however registration is difficult in sequential imaging. In a Simultaneous MR-PET system many of the issues with sequential imaging are irrelevant. This work presents a novel framework in which to derive a PET image-based input function using multiple MR sequences with the practical consideration of limiting total scan time.