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Abstract #2925

Investigations on Ultrasound Focal Therapy for MRI-Guided Transurethral Treatment of the Prostate: Dual-Frequency Ultrasound Heating in Gel Phantom

William Apoutou N'DJIN1, 2, Charles MOUGENOT3, Ilya KOBELEVSKIY1, Elizabeth RAMSAY1, Michael BRONSKILL1, 2, Rajiv CHOPRA1, 2

1Imaging Research, Sunnybrook Research Institute, Toronto, ON, Canada; 2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; 3Philips Healthcare, Toronto, ON, Canada

The feasibility of transurethral dual-frequency ultrasound focal therapy under MR-thermometry guidance has been investigated experimentally in gel phantom. The therapeutic applicator was inserted into an anatomical gel phantom including clinically approved human prostate geometry and prostate tumor mimics. Full prostate gland therapy and focal therapy strategies have been tested successfully, and allowed accurate and fast treatments (~ half an hour) of all tumor mimics spread in a large prostate (52 cm2). Focal therapy was faster and less aggressive, which can be promising for future clinical studies on MR-guided transurethral ultrasound treatment of localized prostate cancer.