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Abstract #2980

Apparent Diffusion Coefficient Correlation with Different Clinico-Pathological and Molecular Prognostic Factors of Breast Cancer

Luke Bonello1, Giuseppe Petralia2, Paul Summers2, Roberto Di Filippi2, Sara Raimondi2, Giuseppe Renne2, Giuseppe Curigliano2, Massimo Bellomi, 12

1School of Radiology, University of Milan, Milan, Lombardia, Italy; 2European Institute of Oncology, Milan, Italy

We evaluated the correlation of the apparent diffusion coefficient (ADC) obtained from diffusion-weighted magnetic resonance imaging (DW-MRI) with clinico-pathological and molecular prognostic factors of breast cancer in 88 patients. Mean ADC for T4 tumors was higher than for T2 tumors (p<0.05); mean ADC for lymph node positive tumors (N1/N2) was lower than for lymph node negative tumors (p&#8804;0.02). No significant differences in ADC between the 4 different gene profiling subgroups of breast cancer (Luminal A, Luminal B, HER-2, Triple Negative) were identified. Our results suggest that ADC can potentially serve as an additional non-invasive clinical prognostic factor in breast cancer.