Abstract #2986

Apparent Diffusion Coefficient (ADC) Measurements in Normal Fibroglandular Breast Tissue for Women at High Risk of Developing Breast Cancer Compared to Normal Individuals.

Elizabeth AM O'Flynn¹, Veronica A. Morgan², Sharon L. Giles, Erica Scurr, Nina Tunariu, Nandita M. deSouza

¹Cancer Imaging Centre, Institute of Cancer Research and the Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom; ²Cancer Imaging Centre, Institute of Cancer Research and the Royal Marsden NHS Foundation Trust, United Kingdom

ADC values in the normal fibroglandular breast tissue for women at high risk of developing breast cancer have not yet been documented. 24 high risk women and 12 volunteers were scanned during the proliferative phase of the menstrual cycle. Pixel-by-pixel ADChigh (omitting b=0) was computed from a monoexponential fit. There was a significant difference between the mean ADChigh value (x10-6mm2/s) in high risk women (1893+/-251) compared to normal risk women (1689+/-237)(p=0.036). The ADChigh centiles in high risk women were also significantly higher than volunteers in the proliferative phase, although skewness was similar for the two groups (p=0.165).