Kemal Tuncali1, Andriy Fedorov1, Fiona M. Fennessy1, Sandeep N. Gupta2, Junichi Tokuda1, Sam Song1, Nobuhiko Hata1, Robert V. Mulkern1, 3, Clare M. Tempany<s
1Radiology, Brigham and Women's Hospital, Boston, MA, United States; 2GE Global Research Center, Niskayuna, NY, United States; 3Children's Hospital, Boston, MA, United States
Twelve patients enrolled in our study had 3T multiparametric MRI (mpMRI) of the prostate. T2WI, ADC maps from DWI, and pharmacokinetic maps from DCE were evaluated by three radiologists who selected targets and rated them for degree of suspicion of cancer. 67 targets were selected and biopsied using transperineal approach and 3T MRI guidance. Biopsy outcome of cancer was correlated with mpMRI ratings. Calculated ROC curves and test metrics suggested that at least two parameters, ADCb500 and ve, should be combined to select targets for imaging-guided prostate biopsy in order to increase sensitivity and PPV for detecting prostate cancer.