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Abstract #3008

Quantitative Correlation Between DCE-MRI and Broadband Diffuse Optical Spectroscopy Imaging in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy

Shanshan Xu1, 2, Ming-Jung Kim3, 4, Jeon-Hor Chen3, 5, Orhan Nalcioglu3, Bruce J. Tromberg1, 2, Enrico Gratton1, 2, Min-Ying L. Su3

1Biomedical Engineering Department, University of California, Irvine, CA, United States; 2Beckman Laser Institute, Irvine, CA, United States; 3Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, CA, United States; 4Department of Radiology, Yonsei University College of Medicine, Seoul, Korea, Republic of; 5Department of Radiology, China Medical University Hospital, Taichung, Taiwan

A quantitative correlation study was performed between optical parameters measured by Diffuse Optical Spectroscopy Imaging (DOSI) and DCE-MRI kinetic parameters in breast cancer patients undergoing neoadjuvant chemotherapy. In patients who achieved pathologic complete response, DOSI parameters (oxyhemoglobin, deoxyhemoglobin and oxygen saturation) were strongly correlated with Ktrans and kep. This relationship was changed or became weaker after chemotherapy. In patients who did not achieve pCR, there was no significant correlation between any DOSI and DCE-MRI parameters in both baseline and follow-up studies. Different findings were seen between these two groups, suggesting that these relationships may be explored for predicting therapeutic response.