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Abstract #3018

MR Vessel Imaging for Tumor Angiogenesis Quantification in Two Rodent Models of Hepatocellular Carcinoma

Ning Jin1, 2, Yang Guo3, Rachel Klein3, Andrew C. Larson3, 4

1Siemens Healthcare, Columbus, OH, United States; 2Department of Radiology, Northwestern University , Chicago, IL, United States; 3Department of Radiology, Northwestern University, Chicago, IL, United States; 4Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, United States

Hepatocellular carcinoma (HCC) are typically hypervascular tumors. Angiogenesis, the process by which new vessels develop from pre-existing microvessels, plays an important role in HCC progression. The aim of our study was to evaluate MR vessel imaging techniques for tumor angiogenesis quantification in rat models of HCC. Two different rodent HCC models were chosen: McA-RH7777 Morris hepatoma model and N1-S1 hepatoma model.