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Abstract #3028

Automated Design and Low Cost Production of Patient-Specific MRI-Based Prostate Molds for the Correlation of MRI with Histopathology

Marcelino Bernardo1, 2, Dagane Daar1, 2, Baris Turkbey1, Maria J. Merino3, Peter Pinto4, Peter L. Choyke1

1Molecular Imaging Program, National Cancer Institute, Bethesda, MD, United States; 2SAIC-Frederick, Frederick, MD, United States; 3Laboratory of Pathology, National Cancer Institute, Bethesda, MD, United States; 4Urology Oncology Branch, National Cancer Institute, Bethesda, MD, United States

The correlation of prostate MRI to whole-mount sections is essential in order to validate MRI findings. Tissue blocks with the correct location, orientation and shape can be obtained by cutting the deformable prostatectomy specimen inside a mold designed from the patients MRI. In this work, we describe and demonstrate an automated method for designing these molds and creating them using open source software and a low cost 3-D printer. It should be practical in large population studies necessary to compile a training set for developing a decision support system for detecting and localizing prostate cancer.