Abstract #3047

Iterative Decomposition of Water and Fat with Echo Asymmetry and Least-Squares Estimation (IDEAL) Imaging of Multiple Myeloma: Discriminant Analysis for Differentiation of Tumor Staging

Miyuki Takasu¹, Chihiro Tani¹, Miho Ishikawa¹, Daisuke Komoto¹, Keizo Tanitame¹, Yuji Akiyama¹, Yoshiaki Kuroda², Akira Sakai³, Kazuo Awai¹

¹Department of Diagnostic Radiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan; ²Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan; ³Department of Hematology, Fukushima Medical University Hospital, Fukushima, Japan

The present study was performed to prospectively evaluate the effectiveness of IDEAL MRI for discrimination of tumor stage in patients with multiple myeloma without visible focal lesions. The fat signal fractions among the four groups were compared with post hoc test. The fat signal fraction and 2m-to-albumin ratio were entered into discriminant analysis. Among the four groups, patients with symptomatic myeloma showed the lowest fat signal fraction. With the discriminant analysis, 22 of the 24 patients (92%) were correctly classified in each category. Fat quantification using the IDEAL sequence was significantly different when comparing patients with symptomatic and asymptomatic myeloma.