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Abstract #3047

Iterative Decomposition of Water and Fat with Echo Asymmetry and Least-Squares Estimation (IDEAL) Imaging of Multiple Myeloma: Discriminant Analysis for Differentiation of Tumor Staging

Miyuki Takasu1, Chihiro Tani1, Miho Ishikawa1, Daisuke Komoto1, Keizo Tanitame1, Yuji Akiyama1, Yoshiaki Kuroda2, Akira Sakai3, Kazuo Awai1

1Department of Diagnostic Radiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan; 2Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan; 3Department of Hematology, Fukushima Medical University Hospital, Fukushima, Japan

The present study was performed to prospectively evaluate the effectiveness of IDEAL MRI for discrimination of tumor stage in patients with multiple myeloma without visible focal lesions. The fat signal fractions among the four groups were compared with post hoc test. The fat signal fraction and 2m-to-albumin ratio were entered into discriminant analysis. Among the four groups, patients with symptomatic myeloma showed the lowest fat signal fraction. With the discriminant analysis, 22 of the 24 patients (92%) were correctly classified in each category. Fat quantification using the IDEAL sequence was significantly different when comparing patients with symptomatic and asymptomatic myeloma.